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PD-L1 (E1L3N?) XP? Rabbit mAb #13684


品牌: CST 目錄號: 13684S
售價: 詢價 規格: 100ul
保存溫度: -20°C

運輸溫度:

4°C
說明書: 點擊閱讀 庫存: 100
詳細說明: Specificity / Sensitivity
 
PD-L1 (E1L3N) XP® Rabbit mAb recognizes endogenous levels of total PD-L1 protein.
 
Source / Purification
 
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PD-L1 protein.

Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).

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欧美亚洲国产片在线播放